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TMAY: Another life-saving Covid drug identified
2022-05-22
PRESENTATION

"But I saw it as my duty to take part in the Recovery trial because I knew that no matter what happened to me, I was doing something positive to help others.

One of the patients enrolled on the trial, Mark Rivvers, 51, from Cambridge, said: "I was in hospital for almost a month, mostly in an intensive-care unit.

"Everything in my body seemed to be fighting against everything else.

"I was on almost constant respiratory support, I developed sepsis, and I had pneumonia all across my lungs.

"But I saw it as my duty to take part in the Recovery trial because I knew that no matter what happened to me, I was doing something positive to help others.

"I'm really pleased about the result with baricitinib and hope that it can now be used to benefit many others."

There are now many drugs that can help fight Covid:

  • anti-inflammatory drugs that stop the immune system overreacting with deadly consequences
  • anti-viral drugs that make it harder for the coronavirus to replicate inside the body
  • antibody therapies that mimic the immune system to attack the virus

Recovery trial joint chief investigator Sir Martin Landray, professor of medicine and epidemiology, at Oxford Population Health, said: "It is now well established that in people admitted to hospital because of severe Covid, an overactive immune response is a key driver of lung damage.

"Today's results not only show that treatment with baricitinib improves the chances of survival for patients with severe Covid-19 but that this benefit is additional to that from other treatments that dampen down the overactive immune response, such as dexamethasone and tocilizumab.

"This opens up the possibility of using combinations of anti-inflammatory drugs to further drive down the risk of death for some of the sickest patients."

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